Preferred Label : OVA BiP Peptide;
NCIt synonyms : OVA-BiP Hybrid Peptide;
NCIt definition : A 19 amino-acid hybrid peptide antigen with immune adjuvant property. OVA-BiP peptide
consists of 8 amino acids from ovalbumin joined via a tripeptide linker to a stretch
of 8 amino acids, the minimum binding domain of BiP (immunoglobulin heavy chain-binding
protein, aka grp78), a member of the heat shock protein (hsp) 70 family. As a chaperon,
BiP binds to newly synthesized, unfolded mu immnoglobulin heavy chains prior to its
assembly with light chains in the endoplasmic reticulum. In conjunction with a tumor
antigen, this hybrid peptide is used to potentiate antigen presentation and consequently
prime cytotoxic T lymphocyte responses.;
Origin ID : C2546;
UMLS CUI : C0879487;
Semantic type(s)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
