Preferred Label : Vaccine-Sensitized Draining Lymph Node Cells;
NCIt synonyms : VDLN Cells;
NCIt definition : Cells isolated from lymph nodes from patients, and activated in vitro to generate
tumor-specific effector T cells. Lymph nodes in the lymphatics draining tumors often
contain T cells that are immunologically sensitized but functionally deficient. Vaccine-sensitized
draining lymph node cells are prepared by isolating these lymphocytes in vitro and
stimulating them with cytokines to differentiate into mature effector cells. Vaccine-draining
lymph node cells may also be produced by pharmacological activation of lymph node-derived
lymphocytes with drugs such as ionomycin or with bacterial toxin; these activated
lymphocytes may be expanded in culture with cytokines such as interleukin-2 prior
to infusion into the patient. (NCI04);
Origin ID : C2542;
UMLS CUI : C0879357;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
