Preferred Label : Y 90 Monoclonal Antibody HMFG1;
NCIt synonyms : Yttrium Y 90 Monoclonal Antibody HMFG1; monoclonal antibody HMFG1, yttrium Y 90; MOAB HMFG1, yttrium Y 90; yttrium Y 90 MOAB HMFG1; Y 90 MoAb HMFG1;
NCIt definition : A radioimmunoconjugate consisting of HMFG1, a humanized monoclonal antibody directed
against the tumor associated antigen mucin-1 (MUC-1), labeled with the beta-emitting
radioisotope yttrium 90 (Y-90), with potential antineoplastic activities. Upon administration,
the monoclonal antibody moiety targets and binds to MUC-1 on the surface of certain
tumor cells. Upon binding and internalization, pemtumomab and delivers a cytotoxic
dose of beta radiation to MUC1-expressing tumor cells. MUC1, a glycoprotein overexpressed
on the surface of a variety of cancer cells, plays a key role in tumor cell survival
and proliferation.;
Drug name : Theragyn;
Origin ID : C2541;
UMLS CUI : C0879349;
Semantic type(s)
- concept_is_in_subset
