Mutant p53 Peptide Pulsed Dendritic Cell Vaccine

Preferred Label : Mutant p53 Peptide Pulsed Dendritic Cell Vaccine;

NCIt synonyms : mutant p53 peptide pulsed DC vaccine; dendritic cell vaccine, mutant p53 peptide pulsed;

NCIt definition : A cancer vaccine consisting of autologous dendritic cells which have been pulsed with a mutant p53 peptide. Vaccination with mutant p53 peptide pulsed dendritic cells may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing mutant p53, resulting in tumor cell lysis. Many tumor cells overexpress mutant p53 proteins, resulting in the loss of apoptosis regulation and abnormal cell proliferation. (NCI04);

Details

Origin ID

C2540;

UMLS CUI

C0879296;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Mutant p53 peptide pulsed dendritic cell vaccine/Sargramostim [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients