Preferred Label : DNMT1 Mixed-Backbone Antisense Oligonucleotide MG 98;
NCIt synonyms : MG-98 oligonucleotide; MG 98;
NCIt related terms : MG98;
NCIt definition : A second-generation, mixed-backbone, phosphorothioate antisense oligonucleotide (ODN)
with potential antitumor activity. MG 98 is a highly specific inhibitor of translation
of the mRNA for human DNA (cytosine-5-)-methyltransferase 1 (DNMT1), hybridizing to
the 3' un-translated region of DNMT1 mRNA. The silencing of DNMT1 translation by MG
98 may result in the prevention or reversal of abnormal methylation of tumor suppressor
genes and ultimately in tumor growth inhibition or tumor regression.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It blocks the production
of a protein called DNA methyltransferase, which helps control gene expression. This
may kill cancer cells that need DNA methyltransferase to grow. It is a type of antisense
oligonucleotide.;
Molecule name : MG-98; MG 98;
Codes from synonyms : CDR0000046689;
Origin ID : C2530;
UMLS CUI : C0796640;
Semantic type(s)
- concept_is_in_subset
