Preferred Label : TF(c)-KLH Conjugate Vaccine;
NCIt synonyms : vaccine, TF (c)-KLH conjugate; TF (c)-KLH conjugate vaccine; vaccine, TF(c)-KLH conjugate; TF(c)-KLH; TF c KLH Conjugate Vaccine;
NCIt definition : A vaccine containing a clustered pancarcinoma carbohydrate antigen, Thomsen-Friedenreich
(TF) antigen, conjugated with keyhole limpet hemocyanin (KLH) with potential antineoplastic
activity. TF antigen is a disaccharide epitope (galactose-beta1-3-N-acetylgalactose),
normally O-linked to serine or threonine of tumor-associated epithelial mucins. This
vaccine contains the TF epitope cluster (c) that is synthesized by linking 3 copies
of the TF epitope on a threonine backbone to achieve the essential immunogenic structure.
KLH is a hapten carrier and serves as an immunostimulant to improve immune recognition.
Vaccination with TF(c)-KLH peptide vaccine may produce antibodies and elicit a cytotoxic
T lymphocyte (CTL) response against those tumor cells expressing TF antigen, resulting
in decreased tumor growth.;
Origin ID : C2529;
UMLS CUI : C0796636;
Semantic type(s)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
