Preferred Label : KSA-KLH Conjugate Vaccine;
NCIt synonyms : KSA-KLH;
NCIt definition : A peptide vaccine containing an epitope of human tumor-associated KSA antigen (Ep-CAM)
conjugated with keyhole limpet hemocyanin (KLH), with potential antineoplastic activity.
KSA antigen, a type-I transmembrane glycoprotein and a cellular adhesion molecule
with a molecular mass of 40 kDa, is overexpressed on the majority of epithelial tumor
cells. KSA antigen is conjugated with KLH, an immunostimulant and a hapten carrier,
to enhance immune recognition. Vaccination with KSA-KLH may result in the production
of antibodies as well as eliciting a cytotoxic T-lymphocyte (CTL) response against
tumor cells expressing the KSA antigen.;
Origin ID : C2520;
UMLS CUI : C0796598;
Semantic type(s)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
