Preferred Label : Hu14.18-IL2 Fusion Protein EMD 273063;
Obsolete resource : true;
NCIt synonyms : Hu 14.18/IL - 2 Fusion Protein; Hu14.18-IL2; Hu14 18-Interleukin-2 Fusion Protein;
NCIt related terms : hu14.18-interleukin-2 fusion protein;
NCIt definition : A recombinant protein consisting of the hu14.18 monoclonal antibody fused to the cytokine
interleukin-2 (IL2) with potential antineoplastic activity. The monoclonal antibody
portion of the hu14.18-IL2 EMD 273063 fusion protein binds to tumor cells expressing
the GD2 antigen (melanoma, neuroblastoma and certain other tumors); the Fc component
of the fusion protein antibody moiety and natural killer (NK) cells mediate antibody-dependent
cell-mediated cytotoxicity (ADCC) and complement-dependent cellular cytotoxicity (CDCC)
towards GD2-expressing tumor cells. The localized IL2 moiety of the fusion protein
stimulates NK and T-cell antitumor cellular immune responses.;
Alternative definition : NCI-GLOSS: An anticancer drug in which hu14.18, a monoclonal antibody, is combined
with interleukin-2. The monoclonal antibody binds to the cancer cells and delivers
IL-2, which stimulates the immune system to destroy the cancer cells.;
NCIt note : See 'Lorukafusp alfa(C162537)';
Concept status : Retired_Concept;
Molecule name : EMD 273063;
NSC code : 721298;
Codes from synonyms : CDR0000046190;
Origin ID : C2509;
UMLS CUI : C1529682;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
