" /> MKC-1 - CISMeF





Preferred Label : MKC-1;

NCIt related terms : Ro 31-7453;

NCIt definition : An orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. In addition, this agent has been shown to inhibit the activities of the oncogenic kinase Akt, the mTOR pathway, and importin-beta, a protein essential to the transport of other proteins from the cytosol into the nucleus.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It may prevent cancer cells from dividing. It belongs to the family of drugs called cell cycle inhibitors.;

UNII : DNZ11VPY7Q;

InChIKey : OVSKGTONMLKNPZ-UHFFFAOYSA-N;

CAS number : 125313-92-0;

Molecule name : Ro 31-7453; R440;

Chemical formula : C22H16N4O4;

Codes from synonyms : CDR0000046177;

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31/05/2025


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