NCIt definition : An orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with
potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization,
blocking the formation of the mitotic spindle, which may result in cell cycle arrest
at the G2/M phase and apoptosis. In addition, this agent has been shown to inhibit
the activities of the oncogenic kinase Akt, the mTOR pathway, and importin-beta, a
protein essential to the transport of other proteins from the cytosol into the nucleus.;
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It may prevent
cancer cells from dividing. It belongs to the family of drugs called cell cycle inhibitors.;