Vadimezan - CISMeF

Preferred Label : Vadimezan;

NCIt synonyms : Dimethyloxoxanthene Acetic Acid; Dimethylxanthenone Acetic Acid; 5,6-Dimethylxanthenone-4-Acetic Acid; DMXAA; 5,6-MexXAA;

NCIt definition : A fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages.;

Alternative definition : NCI-GLOSS: An anticancer drug that is a type of angiogenesis inhibitor.;

UNII : 0829J8133H;

InChIKey : XGOYIMQSIKSOBS-UHFFFAOYSA-N;

CAS number : 117570-53-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 117570-53-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ASA404;

Chemical formula : C17H14O4;

NSC code : 640488;

Codes from synonyms : CDR0000046166; 111630;

Details

Origin ID

C2504;

UMLS CUI

C2930490;

Automatic exact mappings (from CISMeF team)
- vadimezan [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- vadimezan [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- vadimezan [MeSH concept]
- vadimezan [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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