Cisplatin Liposomal

Preferred Label : Cisplatin Liposomal;

NCIt synonyms : Liposomal Cisplatin; STEALTH Liposomal Cisplatin; Cisplatin, Liposomal; STEALTH Liposomal Encapsulated Cisplatin; STEALTH Cisplatin; STEALTH Liposome Cisplatin;

NCIt definition : A synthetic formulation in which the antineoplastic agent cisplatin is encapsulated in lipids. Cisplatin liposomal consists of small aggregates of cisplatin covered by a single lipid bilayer. Encasement in liposomes improves cisplatin's tumor bioavailability and toxicity profile. Liposomal encapsulation does not affect the pharmacological properties of cisplatin directly. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. (NCI04);

Molecule name : SPI-77; SPI-077;

NSC code : 719334;

Details

Origin ID

C2502;

UMLS CUI

C0796445;

CISMeF manual mappings
- Cisplatin liposome (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- SPI-77, liposomal [MeSH Supplementary Concept]
Semantic type(s)
- Inorganic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to BTNT
- stealth liposomal cisplatin [MeSH concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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