Preferred Label : Indium In 111-DOTA-Biotin;
NCIt synonyms : In 111-DOTA-Biotin;
NCIt definition : A radioconjugate of biotin conjugated with the bifunctional, macrocyclic chelating
agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled with indium In 111
(In-111). Biotin is a water-soluble B-complex vitamin, present in minute amounts in
every living cell, while its level in cancerous tissue is higher than that of normal
tissue. In 111-DOTA-Biotin could be used in 3-step pre-targeting radioimmunotherapy
that employs tumor targeting antibody conjugated with streptavidin, the natural ligand
of biotin.;
Origin ID : C2495;
UMLS CUI : C1512685;
Semantic type(s)
- concept_is_in_subset
