NCIt related terms : polifeprosan 20 carmustine implant;
NCIt definition : A synthetic, biodegradable wafer containing the agent carmustine with antineoplastic
activity. Used to deliver drug directly into a brain tumor site and typically implanted
post-surgically, the wafer is made of a biodegradable poly-anhydride copolymer and
contains the nitrosourea carmustine. As an antineoplastic nitrosourea, carmustine
alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption
of DNA function, cell cycle arrest, and apoptosis. Carmustine also carbamoylates proteins,
including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine
is highly lipophilic and crosses the blood-brain barrier readily. (NCI04);
Alternative definition : NCI-GLOSS: A biodegradable wafer that is used to deliver the anticancer drug carmustine
directly into a brain tumor site after the tumor has been removed by surgery.;
Drug name : Gliadel Wafer; Gliadel Wafers; Gliadel;
NCI Metathesaurus CUI : CL381677;
NSC code : 714372;
Codes from synonyms : CDR0000306511; CDR0000306512;