Preferred Label : Promegapoietin;
NCIt definition : Any one of the family of genetically engineered chimeric molecules with strong activity
in promoting megakaryocyte development. Promegapoietin consists of a truncated or
modified interleukin-3 (IL-3) peptide, via a hinge peptide sequence from IgG, linked
to multiple repeats of modified thrombopoietin (c-Mpl ligand). This agent is capable
of activating megakaryocyte progenitor cells into producing platelets mediated through
either IL-3 receptor or Mpl receptor.;
Alternative definition : NCI-GLOSS: A drug given during chemotherapy to increase blood cell regeneration. Promegapoietin
is a colony-stimulating factor that stimulates the production of blood cells, especially
platelets. It is a cytokine and belongs to the family of drugs called hematopoietic
(blood-forming) agents.;
Molecule name : SC 71858;
Codes from synonyms : CDR0000046019;
Origin ID : C2475;
UMLS CUI : C0678075;
Semantic type(s)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
