Preferred Label : Tn(c)-KLH Conjugate Vaccine;
NCIt synonyms : Tn(c)-KLH; Tn c KLH Conjugate Vaccine;
NCIt definition : A vaccine containing a clustered pancarcinoma carbohydrate antigen conjugated with
keyhole limpet hemocyanin (KLH) with potential antineoplastic activity. Alpha-N-acetylgalactosamine
(Tn) is a monosaccharide usually O-linked to serine or threonine residues of mucins
found on most epithelial cancers with the highest expression on prostate cancer. This
vaccine contains the Tn epitope cluster (c) that is synthesized by linking 3 copies
of the Tn epitope on a threonine backbone to achieve the essential immunogenic structure.
KLH is a hapten carrier and serves as an immunostimulant to improve immune recognition.
Vaccination with Tn(c)-KLH vaccine may produce antibodies and elicit a cytotoxic T
lymphocyte (CTL) response against those tumor cells expressing Tn antigen, resulting
in decreased tumor growth.;
Origin ID : C2474;
UMLS CUI : C0678071;
Semantic type(s)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
