Peptide 946-Tetanus Peptide Conjugate Melanoma Vaccine

Preferred Label : Peptide 946-Tetanus Peptide Conjugate Melanoma Vaccine;

NCIt definition : A melanoma peptide vaccine complexed with tetanus toxoid with potential antineoplastic activity. Peptide 946 contains a melanoma-specific epitope recognized by melanoma-specific cytotoxic T lymphocytes (CTL). In addition to the peptide 946 sequence, this vaccine contains tetanus toxin, a protein known to stimulate the induction of CD4 T lymphocytes; it thereby enhances antigen processing and presentation. Vaccination with the peptide 946-tetanus conjugate melanoma vaccine may produce antibodies as well as elicit a cytotoxic T lymphocyte (CTL) response in tumor cells expressing the 946 epitope, thereby decreasing tumor cell growth.;

Details

Origin ID

C2467;

UMLS CUI

C0677987;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Incomplete Freund's Adjuvant/Peptide 946-Tetanus Peptide Conjugate Melanoma Vaccine [NCIt concept]
- Montanide ISA-51/Peptide 946-tetanus peptide conjugate melanoma vaccine [NCIt concept]

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