MUC-2-KLH Vaccine

Preferred Label : MUC-2-KLH Vaccine;

NCIt synonyms : vaccine, MUC-2-KLH; MUC-2-KLH;

NCIt definition : A peptide vaccine containing human mucin 2 (MUC2) protein conjugated with keyhole limpet hemocyanin (KLH), with potential antineoplastic activity. MUC2, a secretory or gel forming glycoprotein expressed predominantly in goblet cells of the gastrointestinal and respiratory tracts, is overexpressed as an aberrant or deglycosylated form in various tumors such as gastric carcinomas and some hormone-refractory prostate cancers. MUC2 protein is conjugated with KLH, an immunostimulant and a hapten carrier, to enhance immune recognition. Vaccination with MUC2-KLH may result in the production of antibodies as well as elicit a cytotoxic T- lymphocyte (CTL) response against tumor cells expressing MUC2.;

Details

Origin ID

C2465;

UMLS CUI

C0677979;

Currated CISMeF NLP mapping
- MUC-2-KLH vaccine [MeSH concept]
- MUC-2-KLH vaccine [MeSH Supplementary Concept]
Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MUC-2-KLH vaccine [MeSH concept]
- MUC-2-KLH vaccine [MeSH Supplementary Concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- MUC-2-KLH Vaccine/QS21 [NCIt concept]

Keyword's position in hierarchy(ies) :

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