NCIt definition : A recombinant form of the endogenous human keratinocyte growth factor with cell growth
promoting activity. Palifermin acts in the manner similar to the endogenous keratinocyte
growth factor that binds to keratinocyte growth factor receptors on the epithelial
cell surface in the lining of mouth and gastrointestinal tract. This results in stimulation
of epithelial cell proliferation, differentiation and upregulation of cytoprotective
mechanisms.;
Alternative definition : NCI-GLOSS: A form of keratinocyte growth factor (KGF) that is made in the laboratory.
KGF stimulates the growth of cells that line the surface of the mouth and intestinal
tract. Kepivance is used to prevent and treat oral mucositis (mouth sores) caused
by high-dose chemotherapy and radiation therapy in leukemia and lymphoma. It is also
being studied in the prevention and treatment of oral mucositis and dysphagia (difficulty
swallowing) in other types of cancer. Kepivance is a type of recombinant human keratinocyte
growth factor.;
UNII : QMS40680K6;
CAS number : 162394-19-6;
Drug name : Kepivance;
Codes from synonyms : CDR0000443028; 20584; CDR0000479005; 92673;