Preferred Label : Aminocamptothecin Colloidal Dispersion;
NCIt synonyms : 9-aminocamptothecin colloidal dispersion; 9AC colloidal dispersion;
NCIt definition : A colloidal dispersion formulation of 9-Aminocamptothecin, a water-insoluble camptothecin
derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby
inhibiting repair of single-strand DNA breakages. Because the terminal lactone ring
of aminocamptothecin required for the agent's antitumor activity spontaneously opens
under physiological conditions to an inactive carboxy form, the drug must be administered
over an extended period of time to achieve effective cytotoxicity.;
Origin ID : C2452;
UMLS CUI : C0677807;
Semantic type(s)
- concept_is_in_subset
