Preferred Label : Monoclonal Antibody 11D10;
NCIt synonyms : 11D10; MoAb 11D10;
NCIt definition : A murine monoclonal anti-idiotype antibody (anti-Id). Anti-Id 11D10 mimics a specific
epitope of the high molecular weight human milk fat globule (HMFG) glycoprotein primarily
expressed by human breast and some other tumor cells at high density. This specific
HMFG epitope is identified by mAb BrE1, which was used as the immunizing antibody,
or Ab1 to generate the anti-Id (Ab2) 11D10. Anti-ID 11D10 reacts specifically with
breast tumor cells and with minimal reactivity with normal tissues. Vaccination with
anti-Id 11D10 induces anti-anti-idiotype antibodies (Ab3) that may react with breast
cancer cell lines expressing the HMFG membrane epitope.;
PubMed : 7533665;
Origin ID : C2446;
UMLS CUI : C0677765;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
