Preferred Label : Sargramostim Plasmid DNA Pancreatic Tumor Cell Vaccine;
NCIt synonyms : GM-CSF plasmid DNA pancreatic tumor cell vaccine;
NCIt definition : A whole cell vaccine comprised of irradiated allogenic pancreatic tumor cells transfected
with a plasmid DNA encoding human sargramostim (GM-CSF). Vaccination results in expression
of GM-CSF, which induces proliferation and differentiation of hematopoietic lineage
cells as well as stimulating macrophage and dendritic cell functions in antigen presentation
and antitumor cell-mediated immunity. Furthermore, administration of this pancreatic
tumor cell vaccine may elicit a cytotoxic T lymphocyte (CTL) response against similar
host tumor cells, resulting in decreased tumor growth.;
Origin ID : C2445;
UMLS CUI : C0677758;
Semantic type(s)
- concept_is_in_subset
