" /> Canarypox-hIL-12 Melanoma Vaccine - CISMeF





Preferred Label : Canarypox-hIL-12 Melanoma Vaccine;

NCIt synonyms : ALVAC-hIL-12; ALVAC-hIL-12 melanoma vaccine;

NCIt definition : A vaccine consisting of a replication-defective recombinant canarypox virus (ALVAC) that encodes the gene for human interleukin-12 (hIL-12). Produced mainly by B-cells, IL-12 is an endogenous cytokine that activates natural killer (NK) cells, promotes cytotoxic T lymphocyte (CTL) responses, induces the release of interferon-gamma (IFN-gamma), and may exhibit antitumor and anti-angiogenic effects. Vaccination with canarypox-hIL-12 melanoma vaccine may stimulate the host immune system to mount an immune response against tumor cells, thereby inhibiting tumor growth and/or metastasis. (NCI04);

NSC code : 689514;

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30/07/2025


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