NCIt definition : An autologous cancer vaccine derived from tumor-specific gp96 heat shock proteins.
Heat shock proteins chaperone peptides through the endoplasmic reticulum, are key
regulators of dendritic cell maturation, migration and antigen processing, and are
involved in T-cell activation. (NCI04);
Alternative definition : NCI-GLOSS: A vaccine made from a patient's tumor cells that may help the body's immune
system kill cancer cells. This vaccine is used to treat kidney cancer, a type of brain
cancer called glioma, and metastatic melanoma (a type of skin cancer that has spread).
It is also being studied in the treatment of other types of cancer.;
UNII : H3598Y1TLJ;
CAS number : 492448-75-6;
Drug name : Oncophage;
Molecule name : HSPPC-96;
NSC code : 725085;
Codes from synonyms : CDR0000513060; CDR0000665433; CDR0000513059; CDR0000471775;