Preferred Label : PA-1-STK Ovarian Carcinoma Vaccine;
NCIt definition : A cell-based cancer vaccine with potential antineoplastic activity. PA-1-STK ovarian
carcinoma vaccine is produced by transducing the ovarian cancer cell line, PA-1, with
the herpes simplex thymidine kinase (HSV-tk) gene, resulting in a cell line, PA-1-STK,
that permanently expresses the HSV tk gene. Upon transfection into malignant cells,
this vaccine is capable of sensitizing tumor cells in response to an antiviral drug
such as ganciclovir, which is readily phosphorylated by the TK enzyme to its active
form. Administration of ganciclovir following PA-1 STK transfection results in enhanced
cytotoxicity of the transfected tumor cells. Additionally, adjacent non-transfected
cells are also killed by the activated antiviral drug, a phenomenon referred to as
the bystander effect that occurs with this type of suicide-gene transfer technique.;
Origin ID : C2428;
UMLS CUI : C0393067;
Semantic type(s)
- concept_is_in_subset
