Oteracil Potassium

Preferred Label : Oteracil Potassium;

NCIt synonyms : Oxonate Potassium; Oxonic Acid, Potassium Salt; OXO; Potassium Oxonate;

NCIt related terms : Oxonate, potassium;

NCIt definition : The potassium salt of oxonate, an enzyme inhibitor that modulates 5- fluorouracil (5-FU) toxicity. Potassium oxonate inhibits orotate phosphoribosyltransferase, which catalyzes the conversion of 5-FU to its active or phosphorylated form, FUMP. Upon oral administration, Oxonate is selectively distributed to the intracellular sites of tissues lining the small intestines, producing localized inhibitory effects within the gastrointestinal tract. As a result, 5-FU associated gastrointestinal toxic effects are reduced and the incidence of diarrhea or mucositis is decreased in 5-FU related therapy.;

UNII : 4R7FFA00RX;

InChIKey : IAPCTXZQXAVYNG-UHFFFAOYSA-M;

CAS number : 2207-75-2;

Chemical formula : C4H2N3O4.K;

NSC code : 28841;

Codes from synonyms : NSC0028841;

Details

Origin ID

C2415;

UMLS CUI

C0393003;

Currated CISMeF NLP mapping
- Oteracil potassium [SMS substance]
- oteracil monopotassium [Drug component]
- potassium oxonate [MeSH concept]
- potassium oxonate [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- potassium oxonate [MeSH concept]
- potassium oxonate [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Chlorodihydroxypyridine/Potassium Oxonate/Tegafur [NCIt concept]

Keyword's position in hierarchy(ies) :

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