Diethylhomospermine

Preferred Label : Diethylhomospermine;

NCIt synonyms : DEHOP; N(1),N(14)-bis(ethyl)homospermine; 1,14-bis(ethylamino)-5,10-diazatetradecane; DEHSPM; N1N14-diethylhomospermine; N1,N14-diethylhomospermine; N1N14-bis(ethyl)norspermine;

NCIt definition : A polyamine analogue with antiproliferative and potential anti-diarrheal activities. Diethylhomospermine (DEHSPM) antagonizes polyamine activity via NMDA receptor glutamine binding site, thereby modulating inotropic stasis and reducing stool volume (anti-diarrhea). However, due to the toxic effects from metabolites of DEHSP, other tetramine derivatives with less toxicity have been developed.;

UNII : 8G6X94GNHO;

CAS number : 119422-08-1;

Details

Origin ID

C2412;

UMLS CUI

C0067118;

Currated CISMeF NLP mapping
- N(1),N(14)-bis(ethyl)homospermine [MeSH concept]
- N(1),N(14)-bis(ethyl)homospermine [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- N(1),N(14)-bis(ethyl)homospermine [MeSH Supplementary Concept]
- N(1),N(14)-bis(ethyl)homospermine [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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