Preferred Label : T4N5 Liposomal Lotion;
NCIt synonyms : Bacteriophage T4 Endonuclease V in Liposomal Lotion; Lotion, T4N5 Liposomal; T4 Endonuclease V Liposomal Lotion;
NCIt related terms : Dimericine;
NCIt definition : A topical lotion that contains the enzyme T4-bacteriophage endonuclease V encapsulated
within liposomes. With topical liposomal delivery, the DNA repair enzyme T4-bacteriophage
endonuclease V is transported into skin cells, where the enzyme enters cell nuclei
and binds to and incises pyrimidine dimers, thereby catalyzing the first reaction
step of the cellular excision repair pathway for removing DNA replication-inhibiting
pyrimidine dimers produced within duplex DNA through exposure to ultraviolet (UV)
irradiation. In vitro and in vivo studies indicate that T4N5 liposomes increases repair
of DNA damage caused by UV irradiation. (NCI05);
Alternative definition : NCI-GLOSS: A lotion being studied in the treatment of skin cancer and a skin condition
called xeroderma pigmentosum. It has an enzyme contained in very tiny, fat-like particles.
The enzyme repairs damage caused by ultraviolet radiation. T4N5 liposomal lotion is
a type of DNA repair enzyme topical agent.;
Drug name : Dimericine;
Codes from synonyms : CDR0000045489; CDR0000583855;
Origin ID : C2408;
UMLS CUI : C0392927;
Semantic type(s)
- concept_is_in_subset
