Preferred Label : Tretinoin Liposome;
NCIt synonyms : Liposomal tretinoin; All-trans-retinoic acid liposomal; Liposomal all-trans-retinoic acid; TretinoinLF; Tretinoin Liposomal;
NCIt definition : An intravenous formulation of tretinoin (vitamin A acid or all-trans retinoic acid)
encased in liposomes. Tretinoin is a naturally occurring retinoic acid agent that
binds to and activates retinoic acid receptors (RAR), effecting changes in gene expression
that lead to cell differentiation, decreased cell proliferation, and inhibition of
carcinogenesis. This agent also inhibits telomerase, leading to telomere shortening
and eventual apoptosis of certain tumor cell types. Liposome encapsulation extends
the half-life of intravenously administered tretinoin.;
Drug name : Atragen;
Molecule name : AR-623;
Origin ID : C2398;
UMLS CUI : C0338222;
Semantic type(s)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
