NCIt definition : A broad-spectrum, semi-synthetic, beta-lactam penicillin antibiotic with bactericidal
activity. Ampicillin binds to and inactivates penicillin-binding proteins (PBP) located
on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes
with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength
and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening
of the bacterial cell wall and causes cell lysis. Ampicillin is stable against hydrolysis
by a variety of beta-lactamases, therefore, can be used in wide range of gram-positive
and -negative infections.;