Preferred Label : Theramide;
NCIt synonyms : N-acetylglucsamnmyl-N-acetylmuramyl-L-Al-D-isoglu-L-Ala-dipalmitoxy propylamide; DTP-DPP;
NCIt definition : A lipophilic disaccharide derivative of muramyl dipeptide (MDP) with strong immunostimulating
activity and used as a vaccine adjuvant. MDP, a component of bacterial cell wall,
is the minimum chemical structure required for macrophage activation. Due to MDP's
toxicity and short duration of action, theramide was developed with improved stability,
and can be administered without a liposome carrier. Theramide stimulates macrophage
activity, which in turn potentiates other immune responses, including the release
of proinflammatory interleukins and tumor necrosis factor alpha (TNF alpha). The release
of these cytokines further augments the activation of cellular and humoral immune
system.;
Origin ID : C2385;
UMLS CUI : C0281665;
Semantic type(s)
- concept_is_in_subset
