Preferred Label : Tyrosinase-KLH;
NCIt definition : A peptide vaccine containing a tyrosinase epitope conjugated with keyhole lymphocyte
hemocyanin (KLH) with potential antineoplastic activity. Tyrosinase, one of the melanoma
differentiation antigens, is the rate-limiting enzyme for melanin synthesis. This
tyrosine epitope is conjugated with KLH, which serves as an immunostimulant and a
hapten carrier, to enhance immune recognition. Vaccination with tyrosinase-KLH peptide
vaccine may produce anti-tyrosinase antibodies as well as elicit a cytotoxic T lymphocyte
(CTL) response against cells expressing tyrosinase antigen, resulting in decreased
tumor growth.;
Origin ID : C2384;
UMLS CUI : C0281633;
Semantic type(s)
- concept_is_in_subset
