Preferred Label : DAB389 Epidermal Growth Factor;
NCIt synonyms : DAB389 EGF;
NCIt definition : A recombinant fusion protein composed of the diphtheria toxin with the receptor-binding
domain replaced by human epidermal growth factor (EGF). When administered, EGF binds
to the endothelial cell growth factor receptor, EGFR, which is upregulated in many
solid tumors. After binding to the EGF receptor, the agent is internalized by the
cell, where the diphtheria toxin moiety exerts its cytotoxic effect, inhibiting protein
synthesis through ADP-ribosylation of elongation factor 2. (NCI04);
Origin ID : C2383;
UMLS CUI : C0281573;
Semantic type(s)
- concept_is_in_subset
