Preferred Label : Mitumomab;
NCIt synonyms : monoclonal antibody BEC2, anti-idiotypic murine; Monoclonal Antibody BEC2; MoAb BEC2;
NCIt definition : A murine anti-idiotypic monoclonal antibody (anti-Id MoAb) that is directed against
an idiotype mimicking a disialoganglioside GD3. GD3 represents a major surface marker
on most human melanoma cells. Due to poor immunogenicity of GD3, anti-Id MoAb BEC2
(Ab2) was raised against a mouse anti-GD3 MoAb, R24 (Ab1). This anti-Id MoAb was shown
to be functionally mimicking GD3 in stimulating an immune response to produce Ab3
that may be used in combination with other adjuvants for treatment of melanomas.;
UNII : KZ9WFQ2NXF;
CAS number : 216503-58-1;
Molecule name : BEC-2;
PubMed : 2056117;
Origin ID : C2382;
UMLS CUI : C4765367;
Semantic type(s)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
