Preferred Label : Vinfosiltine;
NCIt synonyms : Vincaleukoblastine, O4-Deacetyl-3-de(methoxycarbonyl)-3-(((1-(diethoxyphosphinyl)-2-methylpropyl)amin)carbonyl)-,(3(S))-,Sulfate(Salt);
NCIt definition : An aminophosphonate derivative of a vinca alkaloid with potential antineoplastic activity.
Vinfosiltine exerts its antineoplastic action just like its parent compound, vinblastine,
by immobilizing tubulin molecules, thereby interrupting microtubule assembly/disassembly
dynamics. As a result, vinfosiltine prevents mitotic spindle formation and leads to
cell cycle arrest in metaphase.;
UNII : AW1UYE6Q9I;
InChIKey : BOELCLFVOBIXIF-MAKKXPIGSA-N;
CAS number : 123286-00-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 123286-00-0
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G-SRS /a ;
Molecule name : S12363;
Chemical formula : C51H72N5O10P;
Origin ID : C2378;
UMLS CUI : C0281309;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
