Preferred Label : L-Leucyl-L-Leucine Methyl Ester;
NCIt synonyms : LeuLeuOMe; LLME;
NCIt definition : A 2-amino acid compound with immunomodulatory activity. L-leucyl-L-leucine methyl
ester (LLME) is a lysosomotropic agent entering cells via receptor-mediated endocytosis.
LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in
lysosomes. Condensation of LLME leads to lysosomal rupture and DNA fragmentation in
DPPI-expressing immune cells such as cytotoxic T-cells and natural killer cells. Therefore,
this agent may be able to decrease the incidence of graft versus host disease (GVHD)
via cytotoxic T-cell depletion. Furthermore, LLME has the potential in augmenting
antibody production when used in pretreatment of peripheral blood mononuclear cells
(PBMCs), possibly via interfering gene expressions of inflammatory factors.;
CAS number : 13022-42-9;
Origin ID : C2377;
UMLS CUI : C0281255;
See also inter- (CISMeF)
- Semantic type(s)
- concept_is_in_subset
