Triazene Derivative CB10-277

Preferred Label : Triazene Derivative CB10-277;

NCIt synonyms : 1-p-carboxy-3,3-dimethylphenyltriazine;

NCIt definition : A synthetic derivative of dimethylphenyl-triazene related to dacarbazine, with antineoplastic properties. Related to the agent dacarbazine, CB10-277 is converted in vivo to a monomethyl triazene form that alkylates DNA, resulting in inhibition of DNA replication and repair; in addition, this agent may act as a purine analogue, resulting in inhibition of DNA synthesis, and may interact with protein sulfhydryl groups. (NCI04);

Molecule name : CB10-277;

NSC code : 208107;

PubMed : phase II trial shown to be inactive; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394365/;

Details

Origin ID

C2367;

UMLS CUI

C0284098;

Automatic exact mappings (from CISMeF team)
- 1-(4-carboxyphenyl)-3,3-dimethyltriazene [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CB 10277 [MeSH concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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