Preferred Label : M-Azidopyrimethamine;
NCIt synonyms : MZP;
NCIt definition : An antifolate derived from diaminopyrimidine with cytotoxic properties. With a mechanism
of action similar to that of methotrexate (MTX), m-azidopyrimethamine blocks tetrahydrofolate
synthesis, resulting in depletion of nucleotide precursors and inhibition of DNA,
RNA and protein synthesis. This agent is more lipophilic but less potent than MTX.
(NCI04);
NSC code : 382050;
Origin ID : C2366;
UMLS CUI : C0280485;
Semantic type(s)
- concept_is_in_subset
