Preferred Label : Ricin Immunoconjugate;
NCIt synonyms : Immunoconjugate, Ricin;
NCIt definition : A ricin-containing immunotoxin with immunotherapeutic property. Ricin, a plant toxin
extracted from castor beans, inhibits protein synthesis via cleaving ribosomal subunit
28S rRNA. Ricin immunoconjugate consists of specific antibody conjugated with the
blocked ricin (bR), which has the galactose-binding sites of the B-chain blocked while
leaving the ribosome-inactivating ricin A-chain intact, thereby attaining cell-type-specific
immunotoxins.;
Origin ID : C2359;
UMLS CUI : C0280032;
Semantic type(s)
- concept_is_in_subset
