" /> Sodium Butyrate - CISMeF





Preferred Label : Sodium Butyrate;

NCIt synonyms : Butyrate;

NCIt related terms : Butyric Acid, Sodium Salt; Butyrate sodium; Sodium butanoate;

NCIt definition : The sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling.;

UNII : 8RAS91C36W;

InChIKey : MFBOGIVSZKQAPD-UHFFFAOYSA-M;

CAS number : 156-54-7;

Chemical formula : C4H7O2.Na;

NSC code : 174280;

ChEBI ID : CHEBI:64103;

Codes from synonyms : NSC0174280; 01098;

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Keyword's position in hierarchy(ies) : arborescence

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28/05/2025


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