NCIt definition : The sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short
chain fatty acid, competitively binds to the zinc sites of class I and II histone
deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting
in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing
of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes
leads to increased transcriptional activation of various epigenetically suppressed
genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also
increases the expression of other genes and proteins involved in cellular differentiation
and apoptotic signaling.;
UNII : 8RAS91C36W;
InChIKey : MFBOGIVSZKQAPD-UHFFFAOYSA-M;
CAS number : 156-54-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 156-54-7
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