Preferred Label : Di-dgA-RFB4 Immunotoxin;
NCIt synonyms : Monoclonal Antibody Di-dgA-RFB4; Di-dgA-RFB4 Monoclonal Antibody;
NCIt related terms : di-dgA-RFB4;
NCIt definition : An immunotoxin of monoclonal antibody (MoAb) RFB4 covalently linked to two deglycosylated
ricin toxin A-chain (Di-dgA). This agent can be extracted from castor beans. MoAb
RFB4 recognizes CD22 antigen, a B-cell adhesion protein expressed on malignant cells
in about 70 percent of non-Hodgkin lymphoma and chronic lymphocytic leukemia. Ricin
toxin A-chain, a potent protein synthesis inhibitor, was deglycosylated and was used
in this immunoconjugate to avoid hepatic entrapment. This Di-dgA conjugated MoAb RFB4
delivers 7 fold more cytotoxicity than the single dgA immunotoxin against CD22-positive
malignant cells.;
Alternative definition : NCI-GLOSS: An anticancer drug that is a combination of a monoclonal antibody (RFB4)
and an immunotoxin (dgA).;
Codes from synonyms : CDR0000046736;
Origin ID : C2334;
UMLS CUI : C0677768;
Semantic type(s)
- concept_is_in_subset
