Preferred Label : B43-PAP Immunotoxin;
NCIt synonyms : B43 Immunotoxin; B43-Pokeweed Antiviral Protein Immunotoxin; B43-PAP;
NCIt definition : A mouse-derived anti-human CD19 monoclonal antibody linked to pokeweed (Phytolacca
americana) antiviral protein (PAP) with antileukemic activity. The monoclonal antibody
portion specifically binds to the CD19 antigen, a cell surface molecule normally expressed
only by B lymphocytes and follicular dendritic cells, while over-expressed in B-lineage
lymphocytic leukemia cells. Following internalization, PAP, a plant hemitoxin and
a ribosome-inactivating protein, is cleaved from the immunoconjugate and released
into the cytoplasm where it enzymatically removes a single adenine base from a conserved,
surface exposed loop sequence of rRNA leading to inhibition of protein synthesis and
cell growth, but not necessarily cell death.;
Alternative definition : NCI-GLOSS: A toxic substance linked to an antibody that attaches to tumor cells and
kills them.;
Codes from synonyms : CDR0000046150;
Origin ID : C2331;
UMLS CUI : C0796424;
Semantic type(s)
- concept_is_in_subset
