NCIt definition : A corticosteroid that supports a variety of cardiovascular, metabolic, immunologic,
and homeostatic functions, and which binds specifically to the glucocorticoid receptor
(GR; NR3C1). Glucocorticoid binding to GR leads to the transportation of the activated
receptor-glucocorticoid complex to the nucleus, after which it binds to glucocorticoid
response elements (GRE) and regulates the expression of GR-responsive genes.;
Alternative definition : NICHD: A group of corticosteroids that affect carbohydrate metabolism, inhibit corticotropin
secretion, and possess pronounced anti-inflammatory activity.; NCI-GLOSS: A compound that belongs to the family of compounds called corticosteroids
(steroids). Glucocorticoids affect metabolism and have anti-inflammatory and immunosuppressive
effects. They may be naturally produced (hormones) or synthetic (drugs).;