Glutaminase-Asparaginase

Preferred Label : Glutaminase-Asparaginase;

NCIt definition : A dual function enzyme derived from bacterial Acinetobacter glutaminasificans used as an adjuvant in chemotherapy. Acinetobacter glutaminase-asparaginase (AGA) possesses both L-glutaminase and L-asparaginase activities, capable of hydrolyzing glutamine and asparagine, thereby disturbing nitrogen supplies for dividing cells. When co-administered with alkylating agent melphalan, which utilizes amino acid transport systems for cellular uptake, depletion of glutamine by AGA appeared to facilitate melphalan uptake and enhance its cytotoxicity.;

CAS number : 39335-03-0;

NCI Metathesaurus CUI : CL448368;

NSC code : 215140;

Details

Origin ID

C2309;

UMLS CUI

C0071561;

Automatic exact mappings (from CISMeF team)
- polyethylene glycol-glutaminase-asparaginase [MeSH Supplementary Concept]
See also inter- (CISMeF)
- polyethylene glycol-glutaminase-asparaginase [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- polyethylene glycol-glutaminase-asparaginase [MeSH concept]
- polyethylene glycol-glutaminase-asparaginase [MeSH Supplementary Concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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