Tumor Necrosis Factor (GEN)

Preferred Label : Tumor Necrosis Factor (GEN);

NCIt synonyms : Tumor necrosis factor GEN;

NCIt definition : A recombinant form of endogenous Tumor Necrosis Factor alpha manufactured by Genzyme Pharmaceuticals. Tumor necrosis factor-alpha binds to and activates receptors on the cell surface, resulting in modulation of adipocyte metabolism, lysis of tumor cells, and induction of hemorrhagic necrosis of certain transplantable tumors. (NCI04);

Details

Origin ID

C2245;

UMLS CUI

C1519694;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Tumor Necrosis Factor Receptor Superfamily Member 1A [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]

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