Preferred Label : Mureletecan;
NCIt synonyms : MAG-Camptothecin; MAG-CPT;
NCIt related terms : PNU 166148;
NCIt definition : A water-soluble prodrug, consisting of camptothecin covalently linked to polymeric
backbone methacryloylglycynamide, with potential antineoplastic activity. After entering
tumor cells, the active moiety camptothecin is slowly released from mureletecan via
hydrolysis of the ester linkage. Camptothecin, an alkaloid isolated from the Chinese
tree Camptotheca acuminata, binds to and stabilizes the topoisomerase I-DNA covalent
complex. This inhibits the religation of topoisomerase I-mediated single-stranded
DNA breaks and produces potentially lethal double-stranded DNA breaks when encountered
by the DNA replication machinery, resulting in the inhibition of DNA replication and
apoptosis. Compared to camtpothecin, this prodrug formulation increases camptothecin
drug delivery to the tumor site while reducing systemic toxicity.;
UNII : TTJ03QI76T;
CAS number : 246527-99-1;
Molecule name : PNU166148; PNU 166148;
Codes from synonyms : CDR0000046743;
Origin ID : C2234;
UMLS CUI : C1527216;
Semantic type(s)
- concept_is_in_subset
