Preferred Label : MUC1-KLH Conjugate Vaccine;
NCIt synonyms : MUC-1-KLH vaccine; MUC-1 KLH Vaccine; MUC1-KLH VAC;
NCIt definition : A peptide vaccine, containing human tumor-associated epithelial mucin (MUC1) conjugated
with keyhole limpet hemocyanin (KLH), with potential antineoplastic activity. Vaccination
with MUC1-KLH conjugate vaccine may stimulate humoral and cytotoxic T-lymphocyte (CTL)
responses against tumor cells expressing the MUC1 antigen. In this vaccine, MUC1 antigen
is conjugated with KLH, an immunostimulant and a hapten carrier, to enhance immune
recognition. MUC1 antigen, a membrane-bound glycoprotein expressed by most glandular
and ductal epithelial cells, is overexpressed in an aberrant or deglycosylated form
in various cancers such as those of the breast, prostate, and ovary.;
NCI Metathesaurus CUI : CL026306;
Origin ID : C2232;
UMLS CUI : C0879579;
Semantic type(s)
- concept_is_in_subset
