Monoclonal Antibody 4B5 Anti-Idiotype Vaccine

Preferred Label : Monoclonal Antibody 4B5 Anti-Idiotype Vaccine;

NCIt synonyms : MoAb 4B5 anti-idiotype vaccine; 4B5 monoclonal antibody anti-idiotype vaccine;

NCIt definition : A humanized anti-idiotypic (anti-Id) monoclonal antibody (MoAb) that mimics the disialoganglioside GD2 with potential immunostimulating and antineoplastic activities. Upon administration, monoclonal antibody 4B5 anti-idiotype vaccine may elicit both cellular and humoral immune responses against GD2- expressing tumor cells. GD2 is a glycosphingolipid (ceramide and oligosaccharide) that may be highly expressed by melanomas and other neuroectodermal tumors, while only minimally expressed by normal tissues.;

Details

Origin ID

C2227;

UMLS CUI

C0879386;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Alum adjuvant/Monoclonal antibody 4B5 anti-idiotype vaccine [NCIt concept]
- Monoclonal antibody 4B5 anti-idiotype vaccine/Sargramostim [NCIt concept]

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