Preferred Label : Interleukin-12 Gene;
NCIt synonyms : Plasmid IL-12; IL-12 gene; Plasmid DNA Encoding Human Interleukin-12; pIL-12;
NCIt definition : The DNA sequence that encodes the protein cytokine interleukin-12 (IL-12). When introduced
as the complementary DNA (cDNA) form into tumor cells by, for example, a genetically
engineered adenovirus vector, the transfected IL-12 cDNA expresses IL-12 which activates
antitumoral natural killer (NK) cells and CD8 T-cells and stimulates the secretion
of interferon-gamma (IFN-gamma), potentially inhibiting tumor cell metastasis. This
gene therapy may also result in IL-12-mediated inhibition of vascular endothelial
growth factor (VEGF) and enhancement of matrix metalloproteinases (MMPs). (NCI04);
Origin ID : C2222;
UMLS CUI : C0879338;
Semantic type(s)
- concept_is_in_subset
