Preferred Label : Selective Cytokine Inhibitory Drug CC-1088;
NCIt related terms : CDC-801; CC-1088;
NCIt definition : An analog of thalidomide with potential antineoplastic activity that belongs to the
functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs
inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha
(TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial
growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6). (NCI04);
Alternative definition : NCI-GLOSS: A drug that is being studied in the treatment of cancer. It is similar
but not identical to thalidomide. CC-1088 belongs to the family of drugs called angiogenesis
inhibitors.;
UNII : 95HB56U8P8;
CAS number : 192819-27-5;
Molecule name : CC-1088;
Codes from synonyms : CDR0000044967;
Origin ID : C2210;
UMLS CUI : C0879595;
Semantic type(s)
- concept_is_in_subset
