Acridine Carboxamide

Preferred Label : Acridine Carboxamide;

NCIt synonyms : N-(2-(Dimehtylamino)ethyl)acridine-4-carboxamide;

NCIt related terms : DACA; XR-5000;

NCIt definition : A tricyclic acridine-based (or carboxamide-based) drug with dual topoisomerase inhibitor and potential antineoplastic activities. Acridine carboxamide inhibits both topoisomerases I and II and intercalates into DNA, resulting in DNA damage, the disruption of DNA repair and replication, the inhibition of RNA and protein synthesis, and cell death.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It is a type of topoisomerase inhibitor.;

UNII : 0N3V8R4E13;

InChIKey : XBGNERSKEKDZDS-UHFFFAOYSA-N;

CAS number : 89459-25-6;

Molecule name : XR5000; SN 22995;

Codes from synonyms : CDR0000044849; CDR0000044885;

Details

Origin ID

C2203;

UMLS CUI

C0130149;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- DACA, acridine [MeSH concept]
- DACA, acridine [MeSH Supplementary Concept]
- N-(2'-(dimethylamino)ethyl)acridine-4-carboxamide [MeSH Supplementary Concept]
- N-(2'-(dimethylamino)ethyl)acridine-4-carboxamide [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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